To fuse engineering, cell biology, and physiology to understand how cells sense, respond, and remodel their immediate mechanical and biochemical environments for repair and regeneration in health and disease, then to translate that knowledge to clinics domestically and internationally to address global health disparities.
Dr. Platt, Suhaas Anbazhakan, and Platt lab Alumnus Philip Keegan have published an article in the Journal of Biological Chemistry on regulation of cathepsin K by shear stress and TNFa. These two factors were found to act through independent pathways that converge at the point of gene regulation. This work was done to understand how the biomechanical and biochemical environment in children with sickle cell disease lead to an increased risk of stroke. This is also Suhaas's first paper!
Dr. Platt and Platt Lab alumna Dr. Keon-Young Park recently published an article in Nature Scientific Reports on a method for predicting the invasiveness of tumors in individuals based on patients' personal proteolytic profiles.
Akia presented a 5 minute talk at the International Symposium on Ligaments & Tendons (ISL&T) and presented a poster at the Orthopaedic Research Society in Las Vegas, NV. She presented her work analyzing cathepsin activity and collagen degeneration in a supraspinatus tendon injury-induced rat model and in human chronic supraspinatus tendinopathy. Her abstract submitted to the ISL&T qualified her as a finalist for the Savio L-Y. Woo Young Researcher Award, a very prestigious honor in the tendon community (March 2015).