1. Genetic Mutations Associated with Hormone-Positive Breast Cancer in a Small Cohort of Ethiopian Women.
    Schwartz AD, Adusei A, Tsegaye S, Moskaluk CA, Schneider SS, Platt MO, Seifu D, Peyton SR, Babbitt CC. Annals of Biomedical Engineering . 2021 Aug;49(8):1900-1908. PMID: 34142276.

  2. Multiple sites on SARS-CoV-2 spike protein are susceptible to proteolysis by cathepsins B, K, L, S, and V.
    Bollavaram K, Leeman TH, Lee MW, Kulkarni A, Upshaw SG, Yang J, Song H, Platt MO. Protein Science 2021 Jun;30(6):1131-1143. PMID: 33786919.

  3. Effects of Red Blood Cell Sickling on Right Ventricular Afterload in vivo.
    Schreier DA, Hacker TA, Tabima DM, Platt MO, Chesler NC. Experimental Mechanics 2021 Jan;61(1):229-235. PMID: 33776073

  4. Cysteine cathepsins are altered by flow within an engineered in vitro microvascular niche.
    Douglas SA, Haase K, Kamm RD, Platt MO. APL Bioengineering. 2020 Nov 4;4(4):046102. doi: 10.1063/5.0023342. eCollection 2020 Dec. PMID: 33195960

  5. Age-dependent characterization of carotid and cerebral artery geometries in a transgenic mouse model of sickle cell anemia using ultrasound and microcomputed tomography.
    Rivera CP, Li L, Cai S, Pei N, McAlear GE, Bollavaram K, Ariyo OV, Omojola VO, Song H, Alfonso AL, Tan W, Huo Y, Platt MO. Blood, Cells, Molecules, and Disease 2020 Nov;85:102486. PMID: 32841841

  6. Tumor cell-organized fibronectin maintenance of a dormant breast cancer population.
    Barney LE, Hall CL, Schwartz AD, Parks AN, Sparages C, Galarza S, Platt MO, Mercurio AM, Peyton SR. Science Advances 2020 Mar 11;6(11):eaaz4157. doi: 10.1126/sciadv.aaz4157. eCollection 2020 Mar. PMID: 32195352

  7. Sickle Cell Anemia Mediates Carotid Artery Expansive Remodeling That Can Be Prevented by Inhibition of JNK (c-Jun N-Terminal Kinase.
    Song H, Keegan PM, Anbazhakan S, Rivera CP, Feng Y, Omojola VO, Clark AA, Cai S, Selma J, Gleason RL Jr, Botchwey EA, Huo Y, Tan W, Platt MO Arterioscler Thromb Vasc Biol. 2020 May;40(5):1220-1230. doi: 10.1161/ATVBAHA.120.314045. Epub 2020 Mar 12. PMID: 32160775

  8. Reassessing enzyme kinetics: Considering protease-as-substrate interactions in proteolytic networks.
    Ferrall-Fairbanks MC, Kieslich CA, Platt MO Proc Natl Acad Sci USA 2020 Feb 11;117(6):3307-3318. doi: 10.1073/pnas.1912207117. Epub 2020 Jan 24. PMID: 31980525

  9. Dynamic Model of Protease State and Inhibitor Trafficking to Predict Protease Activity in Breast Cancer Cells.
    Shockey WA, Kieslich CA, Wilder CL, Watson V, Platt MO Cell Mol Bioeng 2019 Jun 19;12(4):275-288. doi: 10.1007/s12195-019-00580-5. eCollection 2019 Aug. PMID: 31719914

  10. Predicting Functional Responses of Progenitor Cell Exosome Potential with Computational Modeling.
    Trac D, Hoffman JR, Bheri S, Maxwell JT, Platt MO Davis ME. Stem Cells Transl Med. 2019 Nov;8(11):1212-1221. doi: 10.1002/sctm.19-0059. Epub 2019 Aug 6. PMID: 31385648

  11. Circulating exosomes derived from transplanted progenitor cells aid the functional recovery of ischemic myocardium.
    Saha P, Sharma S, Korutla L, Datla SR, Shoja-Taheri F, Mishra R, Bigham GE, Sarkar M, Morales D, Bittle G, Gunasekaran M, Ambastha C, Arfat MY, Li D, Habertheuer A, Hu R, Platt MO Gibson G, Davis ME. Sci Transl Med. 2019 May 22;11(493):eaau1168. doi: 10.1126/scitranslmed.aau1168. PMID: 31118291

  12. Using Statistical Modeling to Understand and Predict Pediatric Stem Cell Function.
    Shoja-Taheri F, George A, Agarwal U, Platt MO Yang P, Davis ME, Vallabhajosyula P, Kaushal S. Circ Genom Precis Med. 2019 Jun;12(6):e002403. doi: 10.1161/CIRCGEN.118.002403. Epub 2019 May 17. PMID: 31100989

  13. Sequential, but not Concurrent, Incubation of Cathepsin K and L with Type I Collagen Results in Extended Proteolysis.
    Parks AN, Nahata J, Edouard NE, Temenoff JS, Platt MO Sci Rep. 2019 Apr 1;9(1):5399. doi: 10.1038/s41598-019-41782-1. PMID: 30931961

  14. Full-thickness rotator cuff tear in rat results in distinct temporal expression of multiple proteases in tendon, muscle, and cartilage.
    Treviño EA, McFaline-Figueroa J, Guldberg RE, Platt MO, Temenoff JS. J Orthop Res. 2019 Feb;37(2):490-502. doi: 10.1002/jor.24179. Epub 2018 Dec 27.

  15. Long-Term Cryopreservation and Revival of Tissue-Engineered Skeletal Muscle.
    Grant L, Raman R, Cvetkovic C, Ferrall-Fairbanks MC, Pagan-Diaz GJ, Hadley P, Ko E, Platt MO, Bashir R. Tissue Eng Part A. 2019 Jan 9. doi: 10.1089/ten.TEA.2018.0202. [Epub ahead of print]

  16. Implementation and evaluation of a biotechnology research experience for African-American high school students.
    Boyce AS, Avent C, Adetogun A, Servance L, DeStefano L, Nerem R, Platt MO. Eval Program Plann. 2019 Feb;72:162-169. doi: 10.1016/j.evalprogplan.2018.10.004. Epub 2018 Oct 13.

  17. Implementation of a Biomedical Engineering Research Experience for African-American High School Students at a Tier One Research University.
    Avent CM, Boyce AS, Servance LD, DeStefano LA, Nerem RM, Platt MO, J Biomech Eng. 2018 Aug 1;140(8):0847011-8. doi: 10.1115/1.4040310. PMID: 30003257

  18. Human cathepsins K, L, and S: Related proteases, but unique fibrinolytic activity.
    Douglas SA, Lamothe SE, Singleton TS, Averett RD, Platt MO. Biochim Biophys Acta Gen Subj. 2018 Sep;1862(9):1925-1932. doi: 10.1016/j.bbagen.2018.06.015. Epub 2018 Jun 23.

  19. Molecular insights into the irreversible mechanical behavior of sickle hemoglobin.
    Yesudasan S, Douglas SA, Platt MO, Wang X, Averett RD. J Biomol Struct Dyn. 2019 Mar;37(5):1270-1281. doi: 10.1080/07391102.2018.1456362. Epub 2018 May 4.

  20. Co-emergence of Specialized Endothelial Cells from Embryonic Stem Cells.
    Madfis N, Lin Z, Kumar A, Douglas SA, Platt MO, Fan Y, McCloskey KE. Stem Cells Dev. 2018 Jan 10. doi: 10.1089/scd.2017.0205.

  21. Computational predictions of cysteine cathepsin-mediated fibrinogen proteolysis.
    Ferrall-Fairbanks MC, West DM, Douglas SA, Averett RD, Platt MO. Protein Science. 2017 Dec 20. doi: 10.1002/pro.3366.

  22. Development of a Platform for Studying 3D Astrocyte Mechanobiology: Compression of Astrocytes in Collagen Gels.
    Mulvihill JJE, Raykin J, Snider EJ, Schildmeyer LA, Zaman I, Platt MO, Kelly DJ, Ethier CR. Ann Biomed Eng. 2017 Nov 27. doi: 10.1007/s10439-017-1967-5.

  23. Novel in vivo and in vitro techniques to image and model the cerebral vasculature in sickle cell disease.
    Buckley EM, Platt MO, Lam WA. Blood Cells Mol Dis. 2017 Sep;67:114-119. doi: 10.1016/j.bcmd.2017.08.008.

  24. Investigating the Life Expectancy and Proteolytic Degradation of Engineered Skeletal Muscle Biological Machines.
    Cvetkovic C, Ferrall-Fairbanks MC, Ko E, Grant L, Kong H, Platt MO, Bashir R. Scientific Reports. 2017 Jun 19;7(1):3775. doi: 10.1038/s41598-017-03723-8.

  25. Multiplex Cathepsin Zymography to Detect Amounts of Active Cathepsins K, L, S, and V. Platt MO. Methods Mol Biol. 2017;1626:239-252. doi: 10.1007/978-1-4939-7111-4_23.

  26. PACMANS: A bioinformatically informed algorithm to predict, design, and disrupt protease-on-protease hydrolysis.
    Ferrall-Fairbanks MC, Barry ZT, Affer M, Shuler MA, Moomaw EW, Platt MO. Protein Sci. 2017 Apr;26(4):880-890. doi: 10.1002/pro.3113. Epub 2017 Mar 1.
    Use PACMANS here

  27. Supraspinatus tendon overuse results in degenerative changes to tendon insertion region and adjacent humeral cartilage in a rat model.
    Parks AN, McFaline-Figueroa J, Coogan A, Poe-Yamagata E, Guldberg RE, Platt MO, and Temenoff JS. J Orthop Res. 2016 Dec 21. doi: 10.1002/jor.23496. [Epub ahead of print]

  28. Experimental, Systems, and Computational Approaches to Understanding the MicroRNA-Mediated Reparative Potential of Cardiac Progenitor Cell-Derived Exosomes From Pediatric Patients.
    Agarwal U, George A, Bhutani S, Ghosh-Choudhary S, Maxwell JT, Brown ME, Mehta Y, Platt MO , Liang Y, Sahoo S, Davis ME. Circ Res. 2017 Feb 17;120(4):701-712. doi: 10.1161/CIRCRESAHA.116.309935.

  29. Differential cathepsin responses to inhibitor-induced feedback: E-64 and cystatin C elevate active cathepsin S and suppress active cathepsin L in breast cancer cells.
    Wilder CL, Walton C, Watson V, Stewart FA, Johnson J, Peyton SR, Payne CK, Odero-Marah V, Platt MO. Int J Biochem Cell Biol. 2016 Oct;79:199-208. doi: 10.1016/j.biocel.2016.08.030.

  30. Computational imaging analysis of fibrin matrices with the inclusion of erythrocytes from homozygous SS blood reveals agglomerated and amorphous structures.
    Averett RD, Norton DG, Fan NK, Platt MO. J Thromb Thrombolysis. 2016 Sep 23. [Epub ahead of print]

  31. Age-Dependent Effect of Pediatric Cardiac Progenitor Cells After Juvenile Heart Failure.
    Agarwal U, Smith AW, French KM, Boopathy AV, George A, Trac D, Brown ME, Shen M, Jiang R, Fernandez JD, Kogon BE, Kanter KR, Alsoufi B, Wagner MB, Platt MO, Davis ME. Stem Cells Transl Med.2016 Jul;5(7):883-92. doi: 10.5966/sctm.2015-0241.

  32. Sickle cell anemia and pediatric strokes: Computational fluid dynamics analysis in the middle cerebral artery.
    Rivera CP, Veneziani A, Ware RE, Platt MO. Exp Biol Med. 2016 Apr;241(7):755-65. doi: 10.1177/1535370216636722.

  33. Biomechanical and biochemical regulation of cathepsin K expression in endothelial cells converge at AP-1 and NF-kB.
    Keegan PM, Anbazhakan S, Kang B, Pace BS, Platt MO. Biol Chem. 2016 Jan 13

  34. Low-Cost Method to Monitor Patient Adherence to HIV Antiretroviral Therapy Using Multiplex Cathepsin Zymography.
    Platt MO, Evans D, Keegan PM, McNamara L, Parker IK, Roberts LM, Caulk AW, Gleason RL Jr, Seifu D, Amogne W, Penny C. Mol Biotechnol. 2016 Jan;58(1):56-64.

  35. MMP-mediated mesenchymal morphogenesis of pluripotent stem cell aggregates stimulated by gelatin methacrylate microparticle incorporation.
    Nguyen AH, Wang Y, White DE, Platt MO, McDevitt TC. Biomaterials. 2016 Jan;76:66-75. Epub 2015 Oct 21.

  36. Cathepsin Protease Inhibition Reduces Endometriosis Lesion Establishment.
    Porter KM, Wieser FA, Wilder CL, Sidell N, Platt MO. Reprod Sci. 2015 Oct 19. pii: 1933719115611752. [Epub ahead of print]

  37. Endothelial cells and cathepsins: Biochemical and biomechanical regulation. Review
    Platt MO and Shockey WA. Biochimie. 2015 Oct 13. [Epub ahead of print].

  38. Monocyte-derived macrophage assisted breast cancer cell invasion as a personalized, predictive metric to score metastatic risk.
    Park KY, Li G, Platt MO. Scientific Reports. 5, Article number: 13855 (2015) doi:10.1038/srep13855

  39. Muscadine grape skin extract can antagonize Snail-cathepsin L-mediated invasion, migration and osteoclastogenesis in prostate and breast cancer cells.
    Burton LJ, Smith BA, Smith BN, Loyd Q, Nagappan P, McKeithen D, Wilder CL, Platt MO, Hudson T, Odero-Marah VA. Carcinogenesis. 2015 Sep;36(9):1019-27. Epub 2015 Jun 10.

  40. Efavirenz treatment causes arterial stiffening in apolipoprotein E-null mice.
    Caulk AW, Soler J, .Platt MO, and Gleason RL. J Biomech. 2015 May 21. Epub ahead of Print.

  41. Microarchitectural and mechanical characterization of the sickle bone.
    Green M, Akinsami I, Lin A, Banton S, Ghosh S, Chen B, Platt M, Osunkwo I, Ofori-Acquah S, Guldberg R, Barabino G. J Mech Behav Biomed Mater. 2015 Aug;48:220-8.

  42. Experimental and imaging techniques for examining fibrin clot structures in normal and diseased states.
    Fan NK, Keegan PM, Platt MO, and Averett RD. J Vis Exp.2015 Apr 1;(98):e52019.

  43. Cathepsins in Rotator Cuff Tendinopathy: Identification in Human Chronic Tears and Temporal Induction in a Rat Model.
    Seto SP, Parks AN, Qiu Y, Soslowsky LJ, Karas S, Platt MO, and Temenoff JS. Ann Biomed Eng.. 2015 Jan 06 Epub ahead of print.

  44. Identification of Therapeutic Covariant MicroRNA Clusters in Hypoxia-Treated Cardiac Progenitor Cell Exosomes Using Systems Biology.
    Gray WD, French KM, Ghosh-Choudhary S, Maxwell JT, Brown ME, Platt MO, Searles CD, and Davis ME. Circ Res.. 2015 Jan 16;116(2):255-63. COVER. doi: 10.1161/CIRCRESAHA.116.304360.2014

  45. Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD.
    Awojoodu AO, Keegan PM, Lane AR, Zhang Y, Lynch KR, Platt MO, Botchwey EA. Blood. 2014 Sep 18;124(12):1941-50. doi: 10.1182/blood-2014-01-543652. Epub 2014 Jul 29.

  46. Pro-atherogenic shear stress and HIV proteins synergistically upregulate cathepsin K in endothelial cells.
    Parker IK, Roberts LM, Hansen L, Gleason RL Jr, Sutliff RL, Platt MO. Ann Biomed Eng. 2014 Jun;42(6):1185-94. doi: 10.1007/s10439-014-1005-9. Epub 2014 Apr 10.

  47. Bone Microenvironment Tissue Surrogates Engineered for Reporting of Metastasized Breast Cancer Osteolytic Activity.
    Dumas JE, Parks AN, Platt MO. MRS Proceedings 1625 .mrsf13-1625-i01-04. 2014 Jan 1

  48. Crohn's disease: a review of treatment options and current research.
    Bandzar S, Gupta S, Platt MO. Cell Immunol. 2013 Nov-Dec;286(1-2):45-52. doi: 10.1016/j.cellimm.2013.11.003. Epub 2013 Nov 20. Review.

  49. From GRID to gridlock: the relationship between scientific biomedical breakthroughs and HIV/AIDS policy in the US Congress.
    Platt MB and Platt MO. J. International AIDS Society. 2013 November 27; 16:18446.

  50. Kinin-B2 receptor exerted neuroprotection after diisopropylfluorophosphate-induced neuronal damage.
    Torres-Rivera W, Perez D, Park KY, Carrasco M, Platt MO, Eterovic' VA, Ferchmin PA, Ulrich H, Martins AH. Neuroscience. 2013 Sep 5;247:273-9.

  51. Azidothymidine (AZT) leads to arterial stiffening and intima-media thickening in mice.
    Hansen L, Parker I, Monet Roberts L, Sutliff RL, Platt MO, Gleason RL Jr. J Biomech. 2013 May 31;46(9):1540-7.

  52. Systematic optimization of multiplex zymography protocol to detect active cathepsins K, L, S, and V in healthy and diseased tissue: compromise among limits of detection, reduced time, and resources.
    Dumas JE and Platt MO Mol Biotechnol. 2013 Jul;54(3):1038-47.

  53. Endothelial Dysfunction, Arterial Stiffening, and Intima-Media Thickening in Large Arteries from HIV-1 Transgenic Mice.
    Hansen L, Parker I, Sutliff RL, Platt MOGleason RL Jr. Ann Biomed Eng. 2012 Nov 22.

  54. Patient specific proteolytic activity of monocyte-derived macrophages and osteoclasts predicted with temporal kinase activation states during differentiation.
    Keon-Young Park, Weiwei A. Li, and Platt MO. Integrative Biology. 2012 Nov 1.

  55. Cathepsin S cannibalism of cathepsin K as a mechanism to reduce type I collagen degradation.
    Barry ZT and Platt MO. Journal of Biological Chemistry. 2012 Aug 10;287(33):27723-30. Epub 2012 Jun 22.

  56. Tumor necrosis factor alpha stimulates cathepsin K and V activity via juxtacrine monocyte-endothelial cell signaling and JNK activation.
    Keegan PM, Wilder CL, and Platt MO. Molecular and Cellular Biochemistry. 2012 Aug;367(1-2):65-72. Epub 2012 May 5.

  57. Sickle cell disease activates peripheral blood mononuclear cells to induce cathepsins K and V activity in endothelial cells.
    Keegan PM, Surapaneni S, and Platt MO. Anemia. 2012;2012:201781. Epub 2012 Apr 9.

  58. T-cell phosphokinome as a fingerprint of effective graft versus leukemia.
    Platt MO and Kemp ML. Front Biosci (Elite Ed). 2012 Jan 1;4:721-33.

  59. Manipulating substrate and pH in zymography protocols selectively distinguishes cathepsins K, L, S, and V activity in cells and tissues.
    Wilder CL, Park KY, Keegan PM, Platt MO. Archives of Biochemistry and Biophysics. 2011 Sep 29.

  60. VEGF internalization is not required for VEGFR-2 phosphorylation in bioengineered surfaces with covalently linked VEGF.
    Anderson SM, Shergill B, Barry ZT, Manousiouthakis E, Chen TT, Botvinick E, Platt MO, Iruela-Arispe ML, Segura T. Integrative Biology. 2011 Sep;3(9):887-96. Epub 2011 Aug 8.

  61. Multiplex Zymography Captures Stage-specific Activity Profiles of Cathepsins K, L, and S in Human Breast, Lung, and Cervical Cancer.
    Chen B and Platt MO Journal of Translational Medicine, 2011 Jul 14;9:109.

  62. Sickle Cell Biomechanics.
    Barabino GA, Platt MO, Kaul DK. Annu Rev Biomed Eng. 2010 Aug 15;12:345-67. PubMed PMID: 20455701.

  63. Detection of femtomole quantities of mature cathepsin K with zymography.
    Li WA, Barry ZT, Cohen JD, Wilder CL, Deeds RJ, Keegan PM, Platt MO. Analytical Biochemistry. 2010 Mar 3. PubMed PMID: 20206119.

  64. Magnesium as a Biodegradable and Bioabsorbable Material for Medical Implants.
    Brar HS, Platt MO, Sarntinoranont M, Martin PI, and Manuel MV. JOM Journal of the Minerals, Metals and Materials Society.Volume 61, Number 9 31-34, DOI: 10.1007/s11837-009-0129-0

  65. Multipathway kinase signatures of multipotent stromal cells are predictive for osteogenic differentiation: tissue-specific stem cells.
    Platt MO, Wilder CL, Wells A, Griffith LG, Lauffenburger DA. Stem Cells. 2009 Nov;27(11):2804-14. PubMed PMID: 19750537.

  66. Sustained epidermal growth factor receptor levels and activation by tethered ligand binding enhances osteogenic differentiation of multi-potent marrow stromal cells.
    Platt MO, Roman AJ, Wells A, Lauffenburger DA, Griffith LG. J Cell Physiol. 2009 Nov;221(2):306-17. PubMed PMID: 19544388.

  67. Expression of cathepsin K is regulated by shear stress in cultured endothelial cells and is increased in endothelium in human atherosclerosis.
    Platt MO, Ankeny RF, Shi GP, Weiss D, Vega JD, Taylor WR, Jo H. Am J Physiol Heart Circ Physiol. 2007 Mar;292(3):H1479-86. Epub 2006 Nov 10. PubMed PMID: 17098827.

  68. Cyclic pressure and shear stress regulate matrix metalloproteinases and cathepsin activity in porcine aortic valves.
    Platt MO, Xing Y, Jo H, Yoganathan AP. J Heart Valve Dis. 2006 Sep;15(5):622-9. PubMed PMID: 17044366.

  69. Laminar shear stress inhibits cathepsin L activity in endothelial cells.
    Platt MO, Ankeny RF, Jo H. Arterioscler Thromb Vasc Biol. 2006 Aug;26(8):1784 90. Epub 2006 May 18. PubMed PMID: 16709945.

  70. Simulated microgravity using the Random Positioning Machine inhibits differentiation and alters gene expression profiles of 2T3 preosteoblasts.
    Pardo SJ, Patel MJ, Sykes MC, Platt MO, Boyd NL, Sorescu GP, Xu M, van Loon JJ, Wang MD, Jo H. Am J Physiol Cell Physiol. 2005 Jun;288(6):C1211 21. Epub 2005 Feb 2. PubMed PMID: 15689415.

  71. Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a nox1-based NADPH oxidase.
    Sorescu GP, Song H, Tressel SL, Hwang J, Dikalov S, Smith DA, Boyd NL, Platt MO, Lassegue B, Griendling KK, Jo H.Circ Res. 2004 Oct 15;95(8):773-9. Epub 2004 Sep 23. PubMed PMID: 15388638.

  72. Heat shock and cold shock in Deinococcus radiodurans.
    Airo A, Chan SL, Martinez Z, Platt MO, Trent JD. Cell Biochem Biophys. 2004;40(3):277-88. PubMed PMID: 15211028.

  73. Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress stimulates an inflammatory response.
    Sorescu GP, Sykes M, Weiss D, Platt MO, Saha A, Hwang J, Boyd N, Boo YC, Vega JD, Taylor WR, Jo H. J Biol Chem. 2003 Aug 15;278(33):31128-35. Epub 2003 May 23. PubMed PMID: 12766166.